14th NorPEN meeting 16–18 November, 2022

Data-driven decision making in healthcare and health promotion

Tampere University, Main building, Auditorium A1, Kalevantie 4, Tampere, Finland

 Wednesday 16 November, 2022, Pre-conference workshop

13:00–17:00 Workshop on multiple time scales – useful approach in pharmacoepidemiology (own laptops )

In cohort studies with time-to-event outcomes we are usually interested in more than one time-scale. Such time-scales are e.g. time after start of treatment, time after stopping treatment, age, calendar time, and time since diagnosis. Cox’s proportional hazards models allow only one time scale, but with Poisson regression models two or more time-scales can be analyzed simultaneously.  This workshop provides an introduction to understand and analyze multiple time scales. Hands-on practicals provide participants with working R-language scripts. Basic knowledge of the R language is essential for participants.

Theoretical session + hands on practicals with data

Pre-reading materials will be provided for the participants

Working knowledge of R language required for practicals

17:15-18:30 Executive Committee meeting (for representatives and substitutes)

Social program:

19:00 Welcome reception at the Tampere City House, Keskustori 10, Tampere

20:00 PhD student dinner at Sauna Restaurant Kuuma, Laukontori 21, Tampere

Thursday 17 November, 2022, NorPEN meeting

09:00–09:15 Welcome words, Tapio Visakorpi, vice dean, Tampere University (FI)

09:15–12:00 Keynote lectures, chair Jari Haukka, university lecturer, University of Helsinki (FI)

9:15–10:00 Disease prevention in non-communicable diseases and mental disorders, Mika Kivimäki, professor, University College, London (UK)

10:00–10:45 Challenges and opportunities of multi-country, multi-database pharmacoepidemiologic studies, Olaf Klungel, professor, Utrecht University (NL)

10:45–11:15 Coffee

11:15–12:15 Oral presentations, chair Leena Saastamoinen, research manager, Social Insurance Institution (FI)

12:15–13:15 Lunch

13:15–14:30 Session 1 Topic: Prevention interventions in reproductive health, chair Maarit Leinonen, research manager, Finnish Institute for Health and Welfare (FI)

13:15-13:40 Tiina Jääskeläinen, senior lecturer, University of Helsinki (FI): Preeclampsia as a risk factor for cardiovascular disease after pregnancy

13:40-14:05 Hedvig Nordeng, professor, University of Oslo (NO): Risk of childhood cancer after maternal exposure to medications

14:05-14:30 Elena Toffol, postdoctoral researcher, University of Helsinki (FI): Hormonal contraception and mental health: a register-based, nested case-control study from Finland

14:3015:00 Coffee

15:00–15:40 Session 2 Topic: Methodological issues in cancer pharmacoepidemiology, chair Sirpa Hartikainen, professor, University of Eastern Finland (FI)

15:00–15:40 Teemu Murtola, professor, Tampere University (FI): How to avoid common pitfalls in pharmacoepidemiological cancer research?

15:40–17:00 Pharmacoepi slam

15:40–16:45 Slam

16:45–17:00 Q&A

Social program:

19:00 Congress Dinner, Puistotornin juhlasali, Hämeenpuisto 28, Tampere

Friday 18 November, 2022, NorPEN meeting

09:00–10:20 Session 3 Topic: Open and shareable methods for drug use modelling from register-based data, chair Heidi Taipale, assistant professor, Karolinska Institutet (SE), University of Eastern Finland (FI)

9:00–9:20 Laura Pazzagli, statistician, Karolinska Institutet (SE): Exposure definition in pharmacoepidemiology – example of an open source software for treatment episodes construction

9:20–9:40 Henrik Støvring, associate professor, Århus University (DK): Estimation of prescription durations using the reverse Waiting Time Distribution – a general, maximum likelihood-based method

9:40–10:00 Maurizio Sessa, assistant professor (tenure), University of Copenhagen (DK): Sessa empirical estimator: rationale, performance, and applications in real-world data

10:00–10:20 Pia Vattulainen, biostatistician, IQVIA (FI): From Prescriptions to Drug Use Periods (PRE2DUP) R-version

10:20–10:40 Coffee

10:40–11:20 Oral presentations (10 min each), chair Mika Gissler, research professor, Finnish Institute for Health and Welfare (FI)

11:20–12:40 Session 4 Topic: Methodological issues in pharmacovigilance, chair Miia Artama, professor (tenure), Tampere University, Finnish Institute for Health and Welfare (FI)

11:20–12:00 Joan Morris, professor of medical statistics, St Georges´s University of London (UK): Basic methods to combine pharmacoepidemiological data analyzed at different countries

12:00–12:40 Xavier Kurz, head, Data Analytics Workstream European Medicines Agency (NL): Big Health Care Data

12:40–13:00 Closing words and introduction of new Executive Committee and next NorPEN meeting in 2023, History and future of NorPEN, Sirpa Hartikainen, professor, University of Eastern Finland (FI)

13:00-14:00 Lunch and departure